Hepatitis B serological changes following allogeneic bone marrow transplantation

被引:7
|
作者
Teh, B. W. [1 ,2 ]
Slavin, M. A. [1 ,2 ]
Szer, J. [3 ,4 ]
Sasadeusz, J. J. [1 ,5 ]
机构
[1] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia
[2] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[3] Royal Melbourne Hosp, Dept Clin Haematol, Parkville, Vic 3050, Australia
[4] Royal Melbourne Hosp, Bone Marrow Transplant Serv, Parkville, Vic 3050, Australia
[5] Alfred Hosp, Ctr Clin Res Excellence Infect Dis, Prahran, Vic 3181, Australia
关键词
hepatitis B; allogeneic hematopoietic stem cell transplantation; reverse seroconversion; transfusion; occult; STEM-CELL TRANSPLANTATION; VIRUS INFECTION; REVERSE SEROCONVERSION; ANTI-HBS; REACTIVATION; RISK; RECIPIENTS; PATIENT;
D O I
10.1111/j.1399-3062.2012.00762.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hepatitis B (HBV) reverse seroconversion (RS) in immunocompromised patients with serological evidence of past HBV infection (hepatitis B surface antigen [sAg] negative, core antibody [cAb] positive) has been reported with increasing frequency following allogeneic hematopoietic stem cell transplant (allo-HSCT). We performed a retrospective review of serial HBV serological testing in patients who had undergone allo-HSCT at our center between 2000 and 2006. We identified 12 patients with serological evidence of past HBV, including 1 case of RS. Although 7 of these 12 patients had no changes in serological markers detected after transplantation, 5 of them had declining levels of hepatitis B surface antibodies [sAb], with 2 to < 10 IU/mL. The remaining 4 patients with past HBV had loss of antiHBcAb. An additional 14 patients developed isolated antiHBcAb post allo-HSCT in the setting of receiving HBV screened (HBsAg, antiHBcAb) negative donor stem cells. Monitoring of HBV serological markers (including antiHBsAb) and HBV DNA levels pre allo-HSCT in recipients and donors, and post allo-SCT in recipients, would allow early detection and treatment of RS and identify new acquisition of HBV.
引用
收藏
页码:98 / 103
页数:6
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