Application of Hybrid Models to Blood Cell Production in the Bone Marrow

被引：13
|
作者：
Bessonov, N. [1 ,2 ]
Crauste, F. [1 ,3 ]
Fischer, S. [1 ,3 ]
Kurbatova, P. [1 ,3 ]
Volpert, V. [1 ,3 ]
机构：
[1] Univ Lyon 1, Inst Camille Jordan, CNRS, UMR 5208, F-69622 Villeurbanne, France
[2] Inst Mech Engn Problems, St Petersburg 199178, Russia
[3] INRIA Rhone Alpes, Team Project Dracula, Sophia Antipolis, France
来源：
MATHEMATICAL MODELLING OF NATURAL PHENOMENA | 2011年 / 6卷 / 07期
关键词：
hybrid models; erythropoiesis; regulatory mechanisms; SELF-RENEWAL; ERYTHROPOIESIS; DIFFERENTIATION; PROGENITORS; RELEVANCE;
D O I：
10.1051/mmnp/20116701
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
引用
收藏
页码：2 / 12
页数：11
相关论文
共 50 条
  • [41] Response: Nerves to murine bone marrow: Roles in cell production or cell release?
    Benestad, HB
    Iversen, PO
    Nja, A
    BLOOD, 1998, 92 (08) : 2972 - 2973
  • [42] Bone Marrow or Peripheral Blood
    Eapen, Maly
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (06) : 868 - 869
  • [43] BLOOD PRESSURE OF BONE MARROW
    HERZIG, E
    ROOT, WS
    FEDERATION PROCEEDINGS, 1958, 17 (01) : 69 - 69
  • [44] BLOOD AND BONE MARROW PRESERVATION
    ASHWOODSMITH, MJ
    FEDERATION PROCEEDINGS, 1965, 24 (2S15) : S299 - +
  • [45] Determination of cytokeratin expressing cells in blood, bone marrow and blood progenitor cell products
    Gebauer, W
    Gebauer, EF
    Barklage, I
    Schunter, F
    BONE MARROW TRANSPLANTATION, 1999, 23 : S25 - S25
  • [46] Stem Cell Transplantation: Superiority of Fetal Bone Marrow Over Cord Blood and Adult Bone Marrow. • 1290
    M. Michejda
    A. Mazumder
    A. G. Wu
    J. A. Bellanti
    Pediatric Research, 1997, 41 (Suppl 4) : 217 - 217
  • [47] Circadian variations in human peripheral blood on days with and without bone marrow sampling and relation to bone marrow cell proliferation
    Abrahamsen, JF
    Sothern, RB
    Sandberg, S
    Aakvaag, A
    Laerum, OD
    Smaaland, R
    BIOLOGICAL RHYTHM RESEARCH, 1999, 30 (01) : 29 - 53
  • [48] Influence of blood pressure during bone marrow harvest (BMH) on the nucleated cell count of the harvested bone marrow.
    Schimmelpfennig, C
    Dietz, T
    Bräuninger, S
    Geissler, G
    Hermann, S
    Josten, K
    Schwerdtfeger, R
    BLOOD, 1998, 92 (10) : 306B - 306B
  • [49] Blood formatio in bone marrow and bone matter
    Vereby, K
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1943, 69 : 660 - 661
  • [50] Segmentation of Blood and Bone Marrow Cell Images via Learning by Sampling
    Pan, Chen
    Lug, Huijuan
    Caoz, Feilong
    EMERGING INTELLIGENT COMPUTING TECHNOLOGY AND APPLICATIONS, PROCEEDINGS, 2009, 5754 : 336 - +
12345