The regulatory roles of B cell subsets in transplantation

被引:11
|
作者
Chu, Zhulang [1 ,2 ]
Zou, Weilong [3 ]
Xu, Yanan [1 ]
Sun, Qiquan [4 ]
Zhao, Yong [1 ]
机构
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Dept Pathol, Beijing, Peoples R China
[3] Chinese Peoples Armed Police Forces, Surg Transplant & Hepatopancrobiliary, Gen Hosp, Beijing, Peoples R China
[4] Sun Yat Sen Univ, Dept Renal Transplantat, Affiliated Hosp 3, 2693 Kaichuang Ave, Guangzhou 510530, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Antibodies; B cells; graft rejection; immune tolerance; regulatory B cells; ANTIBODY-MEDIATED REJECTION; RENAL-ALLOGRAFT TOLERANCE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CLINICAL OPERATIONAL TOLERANCE; ACUTE LYMPHOBLASTIC-LEUKEMIA; IG-FUSION PROTEINS; T-CELLS; KIDNEY-TRANSPLANTATION; GENE-THERAPY; INTRAVENOUS IMMUNOGLOBULIN;
D O I
10.1080/1744666X.2018.1426461
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: B cells mediate allograft rejection through antigen presentation, and production of cytokines and antibodies. More and more immunosuppressive agents specifically targeting B cells and plasma cells have been applied in clinical transplantation. However, recent studies have indicated the regulatory roles of B cells. Therefore, it is vital to clarify the different effects of B cell subsets in organ transplantation so that we can completely understand the diverse functions of B cells in transplantation.Areas covered: This review focuses on the regulatory roles of B cells in transplantation. B cell subsets with immune modulation and factors mediating immunosuppressive functions of regulatory B (Breg) cells were analyzed. Therapies targeting B cells and the application of B cells for transplant tolerance induction were discussed.Expert commentary: Besides involving rejection, B cells could also play regulatory roles in transplantation. Breg cells and the related markers may be used to predict the immune tolerant state in transplant recipients. New therapeutic strategies targeting B cells should be explored to promote tolerance induction with less impact on the host's protective immunity in organ transplanted patients.
引用
收藏
页码:115 / 125
页数:11
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