Induction of Peroxiredoxins in Transplanted Livers and Demonstration of Their In Vitro Cytoprotection Activity

被引：22
|
作者：
Shau, Hungyi [1 ]
Merino, Alejandro [3 ]
Chen, Lawrence [2 ]
Shih, Charles C. -Y. [4 ]
Colquhoun, Steven D. [2 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Div Surg Oncol, Los Angeles, CA 90095 USA
[2] Cedars Sinai Med Ctr, Ctr Liver Dis & Transplantat, Los Angeles, CA 90048 USA
[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA
[4] PharMingen, Dept Immunol Res, San Diego, CA 92121 USA
来源：
ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 02期
关键词：
D O I：
10.1089/ars.2000.2.2-347
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t-butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation. Antiox. Redox Signal. 2, 347-354.
引用
收藏
页码：347 / 354
页数：8
相关论文
共 50 条
  • [41] Differential induction of NF-κB activity and neural cell death by antidepressants in vitro
    Post, A
    Crochemore, C
    Uhr, M
    Holsboer, F
    Behl, C
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (12) : 4331 - 4337
  • [42] PHYTOCHEMICAL SCREENING, ANTIMICROBIAL ACTIVITY AND in vitro CALLUS INDUCTION IN Datura metel L.
    Ghadage, Ganesh S.
    Bagwan, Rahim A.
    Khan, Javed, V
    Salve, Abhay N.
    APPLIED BIOLOGICAL RESEARCH, 2024, 26 (03) : 370 - 376
  • [43] In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction
    Wang, TianMing
    Shi, GaoXiang
    Shao, Jing
    Wu, DaQiang
    Yan, YuanYuan
    Zhang, MengXiang
    Cui, YanYan
    Wang, ChangZhong
    MICROBIAL PATHOGENESIS, 2015, 87 : 21 - 29
  • [44] Induction of in vitro nuclear apoptosis activity coincides with the production of 50 kDa cytosolic protein
    Naito, M
    Shiina, K
    Mashima, T
    Nagashima, K
    Tsuruo, T
    CELL DEATH AND DIFFERENTIATION, 1997, 4 (07): : 617 - 622
  • [45] Antioxidant enzyme activity induction in murine podocytes precedes in vitro injury by puromycin aminonucleoside
    Vega-Warner, V
    Ransom, RF
    Brosius, FC
    Smoyer, WE
    PEDIATRIC RESEARCH, 2003, 53 (04) : 531A - 531A
  • [46] Induction of early pregnancy factor activity in vitro by platelet-activating factor in mice
    Lash, GE
    Legge, M
    JOURNAL OF REPRODUCTION AND FERTILITY, 1997, 109 (02): : 187 - 191
  • [47] Induction of in vitro nuclear apoptosis activity coincides with the production of 50 kDa cytosolic protein
    Mikihiko Naito
    Kayo Shiina
    Tetsuo Mashima
    Kimie Nagashima
    Takashi Tsuruo
    Cell Death & Differentiation, 1997, 4 : 617 - 622
  • [48] In vitro callus induction and evaluation of antioxidant activity of Rhinacanthus nasutus (L.) Kurz
    Yaowachai, Wipa
    Luecha, Prathan
    Taratima, Worasitikulya
    BIOLOGY METHODS & PROTOCOLS, 2023, 8 (01):
  • [49] Effect of auxins on in vitro rooting of Plumbago zeylanica:: peroxidase activity as a marker for root induction
    Saxena, C
    Samantaray, S
    Rout, GR
    Das, P
    BIOLOGIA PLANTARUM, 2000, 43 (01) : 121 - 124
  • [50] In vitro antiviral activity of distamycin A against clinical isolates of herpes simplex virus 1 and 2 from transplanted patients
    Matteoli, Barbara
    Bernardini, Sara
    Iuliano, Rodolfo
    Parenti, Silvia
    Freer, Giulia
    Broccolo, Francesco
    Baggiani, Angelo
    Subissi, Alessandro
    Arcamone, Federico
    Ceccherini-Nelli, Luca
    INTERVIROLOGY, 2008, 51 (03) : 166 - 172
12345