Induction of Peroxiredoxins in Transplanted Livers and Demonstration of Their In Vitro Cytoprotection Activity

被引：22
|
作者：
Shau, Hungyi [1 ]
Merino, Alejandro [3 ]
Chen, Lawrence [2 ]
Shih, Charles C. -Y. [4 ]
Colquhoun, Steven D. [2 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Div Surg Oncol, Los Angeles, CA 90095 USA
[2] Cedars Sinai Med Ctr, Ctr Liver Dis & Transplantat, Los Angeles, CA 90048 USA
[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA
[4] PharMingen, Dept Immunol Res, San Diego, CA 92121 USA
来源：
ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 02期
关键词：
D O I：
10.1089/ars.2000.2.2-347
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t-butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation. Antiox. Redox Signal. 2, 347-354.
引用
收藏
页码：347 / 354
页数：8
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