Investigation of bioactivity and cell effects of nano-porous sol-gel derived bioactive glass film

被引：11
|
作者：
Ma, Zhijun [1 ]
Ji, Huijiao [2 ]
Hu, Xiaomeng [3 ]
Teng, Yu [1 ]
Zhao, Guiyun [2 ]
Mo, Lijuan [2 ]
Zhao, Xiaoli [2 ]
Chen, Weibo [3 ]
Qiu, Jianrong [1 ]
Zhang, Ming [2 ]
机构：
[1] S China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China
[2] Zhejiang Univ, Coll Life Sci, Hangzhou 310028, Zhejiang, Peoples R China
[3] S China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China
来源：
APPLIED SURFACE SCIENCE | 2013年 / 284卷
基金：
中国国家自然科学基金;
关键词：
bioactive glass film; Nano-porous; Sol-gel; Bone marrow derived mesenchymal stem cells; Cellular effect; IN-VITRO; INCREASED OSTEOBLAST; HEMOSTATIC ACTIVITY; SCAFFOLDS; DIFFERENTIATION; MINERALIZATION; BIOMATERIAL; IMPLANTS; COATINGS; ALUMINA;
D O I：
10.1016/j.apsusc.2013.08.003
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In orthopedic surgery, bioactive glass film coating is extensively studied to improve the synthetic performance of orthopedic implants. A lot of investigations have confirmed that nano-porous structure in bioactive glasses can remarkably improve their bioactivity. Nevertheless, researches on preparation of nano-porous bioactive glasses in the form of film coating and their cell response activities are scarce. Herein, we report the preparation of nano-porous bioactive glass film on commercial glass slide based on a sol-gel technique, together with the evaluation of its in vitro bioactivity through immersion in simulated body fluid and monitoring the precipitation of apatite-like layer. Cell responses of the samples, including attachment, proliferation and osteogenic differentiation, were also investigated using BMSCS (bone marrow derived mesenchymal stem cells) as a model. The results presented here provide some basic information on structural influence of bioactive glass film on the improvement of bioactivity and cellular effects. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码：738 / 744
页数：7
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