Synthesis of enantiomerically pure bicyclic lactams

被引：0

作者：

Diedrichs, N ^{[1
]}

Westermann, B ^{[1
]}

机构：

[1] Univ Gesamthsch Paderborn, Fachbereich chem & Chem Tech, D-33095 Paderborn, Germany

来源：

SYNLETT | 1999年 / 07期

关键词：

Grubbs' catalyst; ring-closing olefin metathesis; PLE; lactams; natural products;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure homologous 1-azabicyclo[x.y.0]alkanones (x = 4-5, y = 4-7) can be synthesized by ring closing olefin metathesis using Grubbs' ruthenium catalyst. By starting from monocyclic lactams, the bicyclic products, even eight- and nine-membered rings, are formed in high yields. The monocyclic lactames can be obtained enantiomerically pure by enzyme-catalyzed kinetic resolution.

引用

页码：1127 / 1129

页数：3

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