MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury

被引：35

作者：

Sohn, Eun Jung ^{[1
]}

Park, Hwan Tae ^{[1
]}

机构：

[1] Dong A Univ, Coll Med, Dept Physiol, Peripheral Neuropathy Res Ctr, Busan, South Korea

来源：

BIOMED RESEARCH INTERNATIONAL | 2018年 / 2018卷

基金：

新加坡国家研究基金会;

关键词：

GUILLAIN-BARRE-SYNDROME; NEUROPATHIC PAIN; GROWTH-FACTOR; SMALL RNAS; MYELINATION; EXPRESSION; PROMOTES; DIFFERENTIATION; REGENERATION; BIOGENESIS;

D O I：

10.1155/2018/8198365

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Schwann cells (SCs) contribute to nerve repair following injury; however, the underlying molecular mechanism is poorly understood. MicroRNAs (miRNAs), which are short noncoding RNAs, have been shown to play a role in neuronal disease. In this work, we show that miRNAs regulate the peripheral nerve system by modulating the migration and proliferation of SCs. Thus, miRNAs expressed in peripheral nerves may provide a potential therapeutic target for peripheral nerve injury or repair.

引用

页数：7

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