Induction of NK cell reactivity against AML and CLL cells by Fc-engineered GITR-Fc fusion proteins

被引：0
|
作者：
Hilpert, J. [1 ]
Schmiedel, B. J. [1 ]
Werner, A. [1 ]
Nuebling, T. [1 ]
Buechele, C. [1 ]
Grosse-Hovest, L. [2 ]
Kanz, L. [1 ]
Salih, H. R. [1 ]
机构：
[1] Univ Tubingen, Dept Hematol & Oncol, Tubingen, Germany
[2] Univ Tubingen, Dept Immunol, Tubingen, Germany
来源：
ONKOLOGIE | 2012年 / 35卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：57 / 58
页数：2
相关论文
共 50 条
  • [31] Development and preclinical characterization of an Fc-optimized CD133 antibody for improved induction of NK cell reactivity against myeloid leukemia
    Koerner, Samuel
    Leibold, Julia
    Grosse-Hovest, Ludger
    Buehring, Hans-Joerg
    Salih, Helmut R.
    Jung, Gundram
    CANCER RESEARCH, 2014, 74 (19)
  • [32] An engineered bi-function fusion protein (CD86-Fc-NKG2a) to reverse NK cell tolerance of malignant cells
    Shuptrine, Casey
    Schreiber, Taylor
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [33] Potent targeting of B cell lymphoma and plasma cell tumors by a tetravalent, Fc-engineered antibody directed against the glycoantigen CD75s.
    Klausz, Katja
    Karimzadeh-Tabrizi, Amir
    Buck, Malena
    Otte, Anna
    Krohn, Steffen
    Kellner, Christian
    Klapper, Wolfram
    Peipp, Matthias
    Gramatzki, Martin
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [34] An Fc-optimized NKG2D-immunoglobulin G fusion protein for induction of natural killer cell reactivity against leukemia
    Steinbacher, Julia
    Baltz-Ghahremanpour, Katrin
    Schmiedel, Benjamin Joachim
    Steinle, Alexander
    Jung, Gundram
    Kuebler, Ayline
    Andre, Maya Caroline
    Grosse-Hovest, Ludger
    Salih, Helmut Rainer
    INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) : 1073 - 1084
  • [35] Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody
    Stefanczyk, Sylwia A.
    Hagelstein, Ilona
    Lutz, Martina S.
    Mueller, Stefanie
    Holzmayer, Samuel J.
    Jarjour, Grace
    Zekri, Latifa
    Heitmann, Jonas S.
    Salih, Helmut R.
    Maerklin, Melanie
    BLOOD CANCER JOURNAL, 2024, 14 (01)
  • [36] Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC
    Repp, Roland
    Kellner, Christian
    Muskulus, Anja
    Staudinger, Matthias
    Nodehi, Sahar Mohseni
    Glorius, Pia
    Akramiene, Dalia
    Dechant, Michael
    Fey, Georg H.
    van Berkel, Patrick H. C.
    van de Winkel, Jan G. J.
    Parren, Paul W. H. I.
    Valerius, Thomas
    Gramatzki, Martin
    Peipp, Matthias
    JOURNAL OF IMMUNOLOGICAL METHODS, 2011, 373 (1-2) : 67 - 78
  • [37] FC ENGINEERED ANTI-CD33MAB POTENTIATES CYTOTOXICITY OF MBIL-21 EXPANDED NK-CELLS AGAINST PRIMARY AML PRE-TREATED WITH DECITABINE
    Mani, R.
    Rajgolikar, G.
    Nunes, J.
    Zapolnik, K.
    Wasmuth, R.
    Mo, X.
    Byrd, J.
    Lee, D. A.
    Muthusamy, N.
    Vasu, S.
    CYTOTHERAPY, 2019, 21 (05) : S20 - S20
  • [38] Inducing specific reactivity against B cells in mice by immunizing with an Fc fusion protein containing self-Igβ
    Jim J. Sheu
    Janice Huang
    Tse W. Chang
    Cancer Immunology, Immunotherapy, 2002, 51 : 145 - 152
  • [39] Inducing specific reactivity against B cells in mice by immunizing with an Fc fusion protein containing self-Igβ
    Shen, JJC
    Huang, J
    Chang, TW
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2002, 51 (03) : 145 - 152
  • [40] Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells
    Schlaeth, Martin
    Berger, Sven
    Derer, Stefanie
    Klausz, Katja
    Lohse, Stefan
    Dechant, Michael
    Lazar, Greg A.
    Schneider-Merck, Tanja
    Peipp, Matthias
    Valerius, Thomas
    CANCER SCIENCE, 2010, 101 (05) : 1080 - 1088
12345