Polarized multispectral imaging in a rigid endoscope based on elastic light scattering spectroscopy

被引：22
|
作者：
Qi, Ji [1 ,2 ]
Barriere, Clement [1 ,2 ]
Wood, Tobias C. [1 ]
Elson, Daniel S. [1 ,2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Inst Global Hlth Innovat, Hamlyn Ctr Robot Surg, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London SW7 2AZ, England
来源：
BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 09期
基金：
欧洲研究理事会;
关键词：
CELLULAR STRUCTURES; DYSPLASIA; CULTURES; TISSUE; BREAST;
D O I：
10.1364/BOE.3.002087
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Elastic light scattering spectroscopy (LSS) is widely utilized to investigate cellular structures in cultured cells and various tissues. However, few imaging systems, especially endoscopic imaging systems, can implement LSS. It is the aim of this work to create a polarized multispectral imaging system based around a rigid endoscope to detect micrometer sized particles using LSS. The instrument first validated with different sized mono-disperse polystyrene microspheres, then an image is reconstructed based on LSS which shows the differentiation of different sized microspheres. Finally a preliminary experiment is conducted to demonstrate its capability to discriminate different types of cells.
引用
收藏
页码：2087 / 2099
页数：13
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