Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone

被引：50
|
作者：
Drzymala, Sarah S. [1 ]
Binder, Jennifer [2 ]
Brodehl, Antje [1 ]
Penkert, Martin [3 ]
Rosowski, Mark [2 ]
Garbe, Leif-Alexander [4 ]
Koch, Matthias [1 ]
机构：
[1] BAM Fed Inst Mat Res & Testing, Dept Analyt Chem, Reference Mat, D-12489 Berlin, Germany
[2] Tech Univ Berlin, Dept Biotechnol, Inst Med Biotechnol, D-13355 Berlin, Germany
[3] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany
[4] Tech Univ Berlin, Dept Biotechnol, Inst Bioanalyt, D-13355 Berlin, Germany
来源：
TOXICON | 2015年 / 105卷
关键词：
Zearalenone; Mycotoxin; MCF-7; E-screen assay; Estrogenicity; Isomerization; ENDOCRINE-DISRUPTING CHEMICALS; DERIVATIVES;
D O I：
10.1016/j.toxicon.2015.08.027
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, alpha-cis-zearalenol and beta-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10 / 12
页数：3
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