Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone

被引：50

作者：

Drzymala, Sarah S. ^{[1
]}

Binder, Jennifer ^{[2
]}

Brodehl, Antje ^{[1
]}

Penkert, Martin ^{[3
]}

Rosowski, Mark ^{[2
]}

Garbe, Leif-Alexander ^{[4
]}

Koch, Matthias ^{[1
]}

机构：

[1] BAM Fed Inst Mat Res & Testing, Dept Analyt Chem, Reference Mat, D-12489 Berlin, Germany

[2] Tech Univ Berlin, Dept Biotechnol, Inst Med Biotechnol, D-13355 Berlin, Germany

[3] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany

[4] Tech Univ Berlin, Dept Biotechnol, Inst Bioanalyt, D-13355 Berlin, Germany

来源：

TOXICON | 2015年 / 105卷

关键词：

Zearalenone; Mycotoxin; MCF-7; E-screen assay; Estrogenicity; Isomerization; ENDOCRINE-DISRUPTING CHEMICALS; DERIVATIVES;

D O I：

10.1016/j.toxicon.2015.08.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, alpha-cis-zearalenol and beta-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：10 / 12

页数：3

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