Effect of a flexible ventricular restraint device on cardiac remodeling after acute myocardial infarction

被引:20
|
作者
Magovern, JA
Teekell-Taylor, L
Mankad, S
Dasika, U
McGregor, W
Biederman, RWW
Yamrozik, J
Trumble, DR
机构
[1] Allegheny Gen Hosp, Dept Cardiovasc & Thorac Surg, Pittsburgh, PA 15212 USA
[2] Allegheny Gen Hosp, Div Cardiol, Pittsburgh, PA 15212 USA
关键词
D O I
10.1097/01.mat.0000199751.51424.78
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The effects of a flexible ventricular restraint device on left ventricular (LV) dilatation and hypertrophy after transmural infarction are examined in an ovine model. Left ventricular remodeling and dilatation occurs after extensive myocardial infarction. A flexible ventricular restraint made from a nitinol mesh was evaluated in adult female sheep (n = 14). Cardiac magnetic resonance imaging scans and hemodynamic measurements were completed before and 6 weeks after anterior myocardial infarction. Treatment animals (n = 7) received passive ventricular restraint concurrently with LV infarction; the others (n = 7) served as controls. Increases in LV end-diastolic volume index were significantly less in the restraint group than in controls (0.20 +/- 0.41 vs 0.83 +/- 0.50 ml/kg, p < 0.03). End-systolic volumes increased less in treatment animals (0.43 +/- 0.28 vs 0.90 +/- 0.38 ml/kg, p < 0.03). Control hearts showed an increase in LV mass after infraction, whereas LV mass decreased in restrained hearts (0.14 +/- 0.19 vs -0.25 +/- 0.36 g/kg, p < 0.03). Hemodynamic studies showed similar changes after infarction for the control and the device group. Gross and microscopic examination showed no device-induced epicardial injury. A flexible ventricular restraint device attenuated remodeling after acute myocardial infarction in sheep.
引用
收藏
页码:196 / 200
页数:5
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