user

Effect of carvedilol on cardiac function and left ventricular remodeling in rats after acute myocardial infarction

被引：0
|
作者：
张军
贾国良
王海昌
机构：
[1] Department of Cardiovasology
[2] Xi’an 710033
[3] China
[4] Fourth Military Medical University
[5] Xijing Hospital
来源：
Journal of Medical Colleges of PLA | 2003年 / 02期
关键词：
carvedilol; myocardial infarction; collagen; left ventricular remodeling;
D O I：
暂无
中图分类号：
R542.22 [];
学科分类号：
摘要：
Objective: To observe the effect of carvedilol injection on left ventricular function and collagen remodelingin rat with myocardial infarction. Methods: Sixty rats with a model of myocardial infarction were randomly divided intonine groups. The rats of therapeutical group were treated with carvedilol injection (2 mg/d intraperitoneal injection)and/or captopil (2 g/L drinking water). Acute myocardial infaction (AMI) group did not receive drug treatment. Theanimals were sacrificed at 4 weeks and 8 weeks after coronary artery ligation. The levels of plasma angiotensin Ⅱ andplasma aldosterone and left ventricle function were determined at different time. The collagen content and the raio of
引用
收藏
页码：69 / 72 +76
页数：5
相关论文
共 50 条
  • [1] Role of Bradykinin on Left Ventricular Remodeling and Cardiac Function after Myocardial Infarction in Rats
    张海柱
    雷立权
    崔长琮
    刘健
    SouthChinaJournalofCardiology, 2009, 10 (02) : 90 - 93
  • [2] Carvedilol prevents remodeling in patients with left ventricular dysfunction after acute myocardial infarction
    Senior, R
    Basu, S
    Kinsey, C
    Schaeffer, S
    Lahiri, A
    AMERICAN HEART JOURNAL, 1999, 137 (04) : 646 - 652
  • [3] Effect of Carvedilol on Parameters of Myocardial Perfusion in Patients With Left Ventricular Remodeling After Myocardial Infarction
    Kamilova, U. K.
    Avesov, D. K.
    Rasulova, Z. D.
    Dzhuraeva, Sh. A.
    KARDIOLOGIYA, 2009, 49 (02) : 66 - 66
  • [4] Left ventricular function and remodeling after myocardial infarction in aging rats
    Raya, TE
    Gaballa, M
    Anderson, P
    Goldman, S
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 273 (06): : H2652 - H2658
  • [5] Effects of carvedilol on left ventricular remodeling after acute myocardial infarction -: The CAPRICORN echo substudy
    Doughty, RN
    Whalley, GA
    Walsh, HA
    Gamble, GD
    López-Sendón, J
    Sharpe, N
    CIRCULATION, 2004, 109 (02) : 201 - 206
  • [6] Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodeling after acute myocardial infarction in rats
    Yang, Y
    Tang, Y
    Ruan, Y
    Li, Y
    Zhou, Y
    Gao, R
    Chen, J
    Chen, Z
    HEART DISEASE: NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT, 2001, : 301 - 310
  • [7] Comparative effects of losartan, carvedilol and their combination in preventing from left ventricular remodeling after acute myocardial infarction in rats
    Yang, Y
    Tang, Y
    Ruan, Y
    Zhang, P
    Zhou, Y
    Gao, R
    Chen, J
    Chen, Z
    HEART DISEASE: NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT, 2001, : 291 - 300
  • [8] Comparative effects of carvedilol and losartan alone and in combination for preventing left ventricular remodeling after acute myocardial infarction in rats
    Yang, YJ
    Tang, YD
    Ruan, YM
    Zhang, P
    Zhou, YW
    Wang, PH
    Gao, RL
    Chen, JL
    Chen, ZJ
    CIRCULATION JOURNAL, 2003, 67 (02) : 159 - 162
  • [9] Effect of L-carnitine on left ventricular remodeling and cardiac function after PCI in patients with acute myocardial infarction
    Ma, Dong
    Wang, Lei
    Xu, Chao
    Yue, Lixia
    Zhang, Jun
    Hao, Jichun
    MINERVA SURGERY, 2022, 77 (04): : 403 - 406
  • [10] Changes in left ventricular function and remodeling after myocardial infarction in hypothyroid rats
    Chen, Yue-Feng
    Redetzke, Rebecca A.
    Said, Suleman
    Beyer, April J.
    Gerdes, A. Martin
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (01): : H259 - H262
12345