Effect of carvedilol on cardiac function and left ventricular remodeling in rats after acute myocardial infarction

被引：0

作者：

张军

贾国良

王海昌

机构：

[1] Department of Cardiovasology

[2] Xi’an 710033

[3] China

[4] Fourth Military Medical University

[5] Xijing Hospital

来源：

Journal of Medical Colleges of PLA | 2003年 / 02期

关键词：

carvedilol; myocardial infarction; collagen; left ventricular remodeling;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

Objective: To observe the effect of carvedilol injection on left ventricular function and collagen remodelingin rat with myocardial infarction. Methods: Sixty rats with a model of myocardial infarction were randomly divided intonine groups. The rats of therapeutical group were treated with carvedilol injection (2 mg/d intraperitoneal injection)and/or captopil (2 g/L drinking water). Acute myocardial infaction (AMI) group did not receive drug treatment. Theanimals were sacrificed at 4 weeks and 8 weeks after coronary artery ligation. The levels of plasma angiotensin Ⅱ andplasma aldosterone and left ventricle function were determined at different time. The collagen content and the raio of

引用

页码：69 / 72 +76

页数：5

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