Regulation of RNA polymerases I and III by the retinoblastoma protein: A mechanism for growth control?

被引：91
|
作者：
White, RJ
机构：
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 03期
关键词：
D O I：
10.1016/S0968-0004(96)10067-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The retinoblastoma protein, RE, is an important tumour suppressor. Recent studies have shown that it inhibits the synthesis of both rRNA and tRNA by RNA polymerases I and III. Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression.
引用
收藏
页码：77 / 80
页数：4
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