In-utero arsenic exposure and growth of infants from birth to 6 months of age: a prospective cohort study in rural Bangladesh

被引:7
|
作者
Wai, Kyi Mar [1 ]
Ser, Ping Han [1 ]
Ahmad, Sk Akhtar [2 ]
Yasmin, Rabeya [2 ]
Ito, Yasunori [3 ]
Konishi, Shoko [1 ,4 ]
Umezaki, Masahiro [1 ]
Watanabe, Chiho [1 ,5 ]
机构
[1] Univ Tokyo, Grad Sch Med, Sch Int Hlth, Dept Human Ecol, Tokyo 1130033, Japan
[2] Bangladesh Univ Hlth Sci, Dept Occupat & Environm Hlth, Dhaka, Bangladesh
[3] IDEA Consultants Int, Inst Environm Ecol, Shizuoka, Japan
[4] Univ Washington, Dept Anthropol, Seattle, WA 98195 USA
[5] Natl Inst Environm Studies, Tsukuba, Ibaraki, Japan
关键词
Arsenic; growth; head circumference; cohort; Bangladesh; HEAD CIRCUMFERENCE; COGNITIVE FUNCTION; CHILD-DEVELOPMENT; DRINKING-WATER; AIR-POLLUTION; BRAIN GROWTH; FETAL; PREGNANCY; SIZE; LIFE;
D O I
10.1080/09603123.2019.1597835
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Arsenic exposure in postnatal life impacts the growth of children, but little is known about the effect of in-utero arsenic exposure on growth very early in childhood. The aim of this study was to examine the associations between in-utero arsenic exposure and the growth of infants from birth to 6 months of age using monthly follow-up data. A prospective cohort study was conducted in rural areas of Bangladesh with 108 mother-infant pairs. This study identified a negative association between in-utero arsenic exposure and head circumference of infants 1-6 months of age (coefficient = -1.20, 95% confidence interval [CI]: -1.97, -0.42), and the effect was more pronounced in the earlier ages of 1-3 months (coefficient = -0.88, 95% CI: -1.70, -0.05). Because head circumference is considered as a surrogate of brain size, our findings suggest that in-utero arsenic exposure influences brain growth during an important developmental period.
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页码:421 / 434
页数:14
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