Spectral Domain Optical Coherence Tomography (SD-OCT) for Salt Quantification in Blood

The measurement of salt levels in blood assume an essential part in the control of numerous real capacities and is contained in body liquids that vehicle oxygen and supplements. We have performed a pilot work to verify the accuracy of blood salt levels obtained through a Fourier domain optical coherence tomography (FD-OCT) simulation approach using MATLAB experimentally with spectral-domain OCT (SD-OCT). Different concentrations of salt were admixed in water, blood plasma and whole blood samples have been investigated to monitor the effect of salt on whole blood using optical coherence tomography. We have successfully measured the viscosity of these samples by measuring the autocorrelation function based on M-mode data under dynamic light scattering in the Brownian motion regime. The effect of the shape of erythrocytes/aggregations on the signal in case of the whole blood sample has been explored exclusively. Conclusively, the diffusion of salt changes the refractive indices of mediums and increases aggregation of erythrocytes and forms rouleaux in whole blood. Autocorrelation functions in the simulation approach of optical coherence tomography were processed by applying inverse Fourier transforms to get the depth profiles of the characteristic signal. The relation between concentrations of salt and viscosity of signal yield the straight-line regressions.