Relationship of human papillomavirus to ploidy in squamous cell carcinomas of the head and neck

被引：3

作者：

Rodrigo, JP

Alvarez, I

Martínez, JA

Lazo, PS

Ramos, S

Suárez, C

机构：

[1] Hosp Leon, Dept Otolaryngol, Leon, Spain

[2] Univ Oviedo, Hosp Cent Asturias, Dept Otolaryngol, E-33080 Oviedo, Spain

[3] Univ Oviedo, Dept Mol Biol, Oviedo, Spain

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 1999年 / 121卷 / 03期

关键词：

D O I：

10.1016/S0194-5998(99)70191-9

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

To establish the relationship between the presence of human papillomavirus (HPV) gene sequences and the development of genetic abnormalities, 31 squamous cell carcinomas of the head and neck were studied for the presence of HPV types 6b and 16 and the DNA content by flow cytometry. Eighteen (58%) cases were aneuploid. HPV DNA was present in seven (22.5%) tumors. Five of them were positive for the HPV type 6b and two for the HPV type 16. Aneuploidy was correlated with poorly differentiated tumors. No correlation was found between the presence of HPV, DNA content, or tumor differentiation. Consequently the presence of HPV gene sequences does not seem to be related to a higher incidence of genetic abnormalities in squamous cell carcinomas of the head and neck.

引用

页码：318 / 322

页数：5

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