C-Acylation of Cyclopropanols: Preparation of Functionalized 1,4-Diketones

被引：105

作者：

Parida, Bibhuti Bhusan ^{[1
]}

Das, Pragna Pratic ^{[1
]}

Niocel, Mathilde ^{[1
]}

Cha, Jin Kun ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

基金：

美国国家科学基金会;

关键词：

PALLADIUM-CATALYZED ACYLATION; CARBON BOND FORMATION; 1,4-DICARBONYL COMPOUNDS; CONJUGATE ADDITION; ORGANIC-SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; STETTER REACTION; ACID-CHLORIDES; REAGENTS; KETONES;

D O I：

10.1021/ol400666x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.

引用

页码：1780 / 1783

页数：4

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