C-Acylation of Cyclopropanols: Preparation of Functionalized 1,4-Diketones

被引：105
|
作者：
Parida, Bibhuti Bhusan [1 ]
Das, Pragna Pratic [1 ]
Niocel, Mathilde [1 ]
Cha, Jin Kun [1 ]
机构：
[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 07期
基金：
美国国家科学基金会;
关键词：
PALLADIUM-CATALYZED ACYLATION; CARBON BOND FORMATION; 1,4-DICARBONYL COMPOUNDS; CONJUGATE ADDITION; ORGANIC-SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; STETTER REACTION; ACID-CHLORIDES; REAGENTS; KETONES;
D O I：
10.1021/ol400666x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.
引用
收藏
页码：1780 / 1783
页数：4
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