Activity induced by a danazol derivative on perfusion pressure and coronary resistance in isolated rat heart

Experimental studies suggest that danazol can be associated with changes in blood pressure. Nevertheless, there is scarce information about the effects of danazol and its derivatives at cardiovascular level. To clarify on this phenomenon, we evaluated the effects of danazol derivative on perfusion pressure in isolated rat heart using Langendorff flow model. Our results demonstrated that pregnenolone-derivative (10(-9) mM) significantly increase the perfusion pressure (p = 0.05) and vascular resistance (p = 0.05) in isolated heart. The activity induced by danazol derivative on perfusion pressure (10(-9) to 10(-4) mM) was blocked in presence of nifedipine (10(-6) mM). These data suggest that activity induced by danazol derivative on perfusion pressure and vascular resistance is dependent upon its chemical structure. This phenomenon involves the L-type calcium channel activation through a non-genomic molecular mechanism.