CD24 Ala/Val polymorphism and multiple sclerosis

被引：23
|
作者：
Goris, An [1 ]
Maranian, Melanie
Walton, Amie
Yeo, Tai Wai
Ban, Maria
Gray, Julia
Dubois, Benedicte
Compston, Alastair
Sawcer, Stephen
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Neurosci, Neurol Unit, Cambridge CB2 2QQ, England
[2] Katholieke Univ Leuven, Sect Expt Neurol, Lab Neuroimmunol, B-3000 Louvain, Belgium
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 175卷 / 1-2期
基金：
英国惠康基金;
关键词：
multiple sclerosis; genetics; association; CD24;
D O I：
10.1016/j.jneuroim.2006.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1180 cases and 1168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：200 / 202
页数：3
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