CD24 Ala/Val polymorphism and multiple sclerosis

被引：23

作者：

Goris, An ^{[1
]}

Maranian, Melanie

Walton, Amie

Yeo, Tai Wai

Ban, Maria

Gray, Julia

Dubois, Benedicte

Compston, Alastair

Sawcer, Stephen

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Neurosci, Neurol Unit, Cambridge CB2 2QQ, England

[2] Katholieke Univ Leuven, Sect Expt Neurol, Lab Neuroimmunol, B-3000 Louvain, Belgium

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 175卷 / 1-2期

基金：

英国惠康基金;

关键词：

multiple sclerosis; genetics; association; CD24;

D O I：

10.1016/j.jneuroim.2006.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1180 cases and 1168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：200 / 202

页数：3

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