Prion and prion-like diseases in animals

被引:34
|
作者
Aguilar-Calvo, Patricia [1 ]
Garcia, Consolacion [1 ]
Carlos Espinosa, Juan [1 ]
Andreoletti, Olivier [2 ]
Maria Torres, Juan [1 ]
机构
[1] Ctr Invest Sanidad Anim CISA INIA, Madrid 28130, Spain
[2] Ecole Natl Vet Toulouse, INRA, UMR Interact Hotes Agents Pathogenes 1225, F-31076 Toulouse, France
关键词
Prion; Amyloid; Amyloidosis; Protein misfolding; Protein self-templating; Prion-like transmission; BOVINE SPONGIFORM ENCEPHALOPATHY; TRANSMISSIBLE MINK ENCEPHALOPATHY; CHRONIC WASTING DISEASE; PROTEIN-A AMYLOIDOSIS; FAMILIAL RENAL AMYLOIDOSIS; LAMBDA-LIGHT CHAIN; WHITE-TAILED DEER; CAPRINE PRP GENE; CLASSICAL SCRAPIE; ATYPICAL SCRAPIE;
D O I
10.1016/j.virusres.2014.11.026
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases characterized by the aggregation and accumulation of the misfolded prion protein in the brain. Other proteins such as beta-amyloid, tau or Serum Amyloid-A (SAA) seem to share with prions some aspects of their pathogenic mechanism; causing a variety of so called prion-like diseases in humans and/or animals such as Alzheimer's, Parkinson's, Huntington's, Type II diabetes mellitus or amyloidosis. The question remains whether these misfolding proteins have the ability to self-propagate and transmit in a similar manner to prions. In this review, we describe the prion and prion-like diseases affecting animals as well as the recent findings suggesting the prion-like transmissibility of certain non-prion proteins. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:82 / 93
页数:12
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