Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (Jaspine B) from D-xylose

被引：57
|
作者：
Du, YG [1 ]
Liu, J
Linhardt, RJ
机构：
[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
[2] Rensselaer Polytech Inst, Dept Chem, Troy, NY 12180 USA
[3] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA
[4] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 03期
关键词：
D O I：
10.1021/jo051644y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first naturally occurring anhydrophytosphingosine, pachastrissamine (jaspine B), a marine compound cytotoxic toward P388, A549, HT29, and MEL28 cell lines at IC50 = 0.01 μg/mL level, has been stereoselectively synthesized from D-xylose in 10 linear steps with 25.7% overall yield. © 2006 American Chemical Society.
引用
收藏
页码：1251 / 1253
页数：3
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