Monogenic human obesity: role of the leptin-melanocortin system in the regulation of food intake and body weight in humans

被引：0

作者：

Gonzalez Jimenez, E. ^{[1
]}

Aguilar Cordero, M. J. ^{[2
]}

Padilla Lopez, C. A. ^{[3
]}

Garcia Garcia, I. ^{[2
]}

机构：

[1] Univ Granada, Dept Enfermeria, Fac Enfermeria, Melilla 52071, Spain

[2] Univ Granada, Dept Enfermeria, Fac Ciencias Salud, Melilla 52071, Spain

[3] Grp PAI Invest CTS 367, Granada, Spain

来源：

ANALES DEL SISTEMA SANITARIO DE NAVARRA | 2012年 / 35卷 / 02期

关键词：

Obesity; Leptin; Melanocortins; Proopiomelanocortin; MC4R; NEUROTROPHIC FACTOR; ENERGY-BALANCE; POMC NEURONS; RECEPTOR; GENE; MUTATIONS; MC4R; BDNF; DISRUPTION; DEFICIENCY;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Human obesity is a disorder of multifactorial origin in which genetic and environmental factors are involved. To understand the mechanisms regulating energy intake and fat accumulation in the body, it is important to study the genetic alterations causing monogenic obesity. Most of the genes involved in monogenic obesity are associated with the leptin-melanocortin system; hence the importance of studying this system by analysing natural mutations in mice. Previous studies have described mutations in leptin and its receptor, proopiomelanocortin and prohormone convertase 1 associated with human obesity of monogenic origin. The aim of this study is to provide an updated review of the main characteristics and functioning of the leptin-melanocortin system, and its implications and potentialities in regulating food intake and body weight.

引用

页码：285 / 293

页数：9

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