IDH1 and IDH2 Mutations in Gliomas

被引：434

作者：

Cohen, Adam L. ^{[1
]}

Holmen, Sheri L. ^{[2
]}

Colman, Howard ^{[3
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Dept Internal Med, Div Med Oncol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Huntsman Canc Inst, Dept Surg, Salt Lake City, UT 84112 USA

[3] Univ Utah, Huntsman Canc Inst, Dept Neurosurg, Salt Lake City, UT 84112 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2013年 / 13卷 / 05期

关键词：

Isocitrate dehydrogenase; Astrocytoma; Oligodendroglioma; Glioblastoma; 2-Hydroxyglutarate; Carcinogenesis; Prognosis; Mutations; INTEGRATED GENOMIC ANALYSIS; HIGH-GRADE GLIOMAS; CODON; 132; MUTATION; ISOCITRATE DEHYDROGENASE; MAFFUCCI SYNDROME; OLLIER DISEASE; IN-VIVO; GLIOBLASTOMA; TUMORS; LEUKEMIA;

D O I：

10.1007/s11910-013-0345-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH. IDH mutations are oncogenic, although whether the mechanism is through alterations in hydroxylases, redox potential, cellular metabolism, or gene expression is not clear. The mutations also drive increased methylation in gliomas. Gliomas with mutated IDH1 and IDH2 have improved prognosis compared with gliomas with wild-type IDH. Mutated IDH can now be detected by immunohistochemistry and magnetic resonance spectroscopy. No drugs currently target mutated IDH, although this remains an area of active research.

引用

页数：7

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