NEUROSCIENCE Memory and the single molecule

被引：25

作者：

Frankland, Paul W. ^{[1
,2
,3
,4
]}

Josselyn, Sheena A. ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

来源：

NATURE | 2013年 / 493卷 / 7432期

关键词：

KINASE M-ZETA; PKM-ZETA; MAINTENANCE; ENHANCEMENT; LTP;

D O I：

10.1038/nature11850

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sustained activity of the brain-specific enzyme PKM-ζ is thought to underlie the maintenance of long-term memories. Studies in PKM-ζ-deficient mice, however, cast the importance of this protein into question. See Letters p.416 & p.420

引用

页码：312 / 313

页数：2

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