NEUROSCIENCE Memory and the single molecule

被引：25
|
作者：
Frankland, Paul W. [1 ,2 ,3 ,4 ]
Josselyn, Sheena A. [1 ,2 ,3 ,4 ]
机构：
[1] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada
[3] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A1, Canada
[4] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada
来源：
NATURE | 2013年 / 493卷 / 7432期
关键词：
KINASE M-ZETA; PKM-ZETA; MAINTENANCE; ENHANCEMENT; LTP;
D O I：
10.1038/nature11850
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sustained activity of the brain-specific enzyme PKM-ζ is thought to underlie the maintenance of long-term memories. Studies in PKM-ζ-deficient mice, however, cast the importance of this protein into question. See Letters p.416 & p.420
引用
收藏
页码：312 / 313
页数：2
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