Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

被引:76
|
作者
Chae, Pil Seok [1 ]
Rana, Rohini R. [2 ]
Gotfryd, Kamil [3 ]
Rasmussen, Soren G. F. [4 ]
Kruse, Andrew C. [4 ]
Cho, Kyung Ho [1 ]
Capaldi, Stefano [2 ]
Carlsson, Emil [2 ]
Kobilka, Brian [4 ]
Loland, Claus J. [3 ]
Gether, Ulrik [3 ]
Banerjee, Surajit [5 ]
Byrne, Bernadette [2 ]
Lee, John K. [6 ]
Gellman, Samuel H. [7 ]
机构
[1] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
[3] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark
[4] Stanford Univ, Stanford, CA 94305 USA
[5] Cornell Univ, NE CAT, Argonne, IL 60439 USA
[6] Univ Minnesota, Dept Biochem, Minneapolis, MN 55455 USA
[7] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
基金
新加坡国家研究基金会;
关键词
FACIAL AMPHIPHILES; DETERGENT; STABILIZATION; RECEPTOR; SOLUBILIZATION; CRYSTALLIZATION; SURFACTANTS; STABILITY; PEPTIDE;
D O I
10.1039/c2cc36844g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).
引用
收藏
页码:2287 / 2289
页数:3
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