Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

被引：28
|
作者：
Marcelino, Monica Yonashiro [1 ]
Borges, Felipe Azevedo [2 ]
Martins Costa, Ana Flavia [3 ]
Singulani, Junya de Lacorte [1 ]
Ribeiro, NathanVinicius [3 ]
Costa-Orlandi, Caroline Barcelos [1 ]
Garms, Bruna Cambraia [2 ]
Mendes-Giannini, Maria Jose Soares [1 ]
Herculano, Rondinelli Donizetti [3 ]
Fusco-Almeida, Ana Marisa [1 ]
机构：
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Clin Anal, Rodovia Araraquara Jau,Km 01-S, Araraquara, SP, Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Biochem & Chem Technol, Araraquara, SP, Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Bioproc & Biotechnol, Araraquara, SP, Brazil
来源：
FUTURE MICROBIOLOGY | 2018年 / 13卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
Candida albicans; fluconazole; natural rubber latex (NRL); BONE REGENERATION GBR; DRUG-DELIVERY; DOSAGE FORMS; MEMBRANES; RELEASE; POLYMER; NANOTECHNOLOGY; BRASILIENSIS; HYDROGELS; CHITOSAN;
D O I：
10.2217/fmb-2017-0154
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.
引用
收藏
页码：359 / 367
页数：9
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