Cell viability monitoring using Fano resonance in gold nanoslit array

被引：18

作者：

Wu, Shu-Han ^{[1
]}

Hsieh, Shu-Yi ^{[2
]}

Lee, Kuang-Li ^{[2
]}

Weng, Ruei-Hung ^{[3
]}

Chiou, Arthur ^{[1
]}

Wei, Pei-Kuen ^{[1
,2
,3
]}

机构：

[1] Natl Yang Ming Univ, Inst Biophoton, Taipei 11221, Taiwan

[2] Acad Sinica, Res Ctr Appl Sci, Taipei 11529, Taiwan

[3] Natl Taiwan Ocean Univ, Dept Mech & Mechatron Engn, Keelung 20224, Taiwan

来源：

APPLIED PHYSICS LETTERS | 2013年 / 103卷 / 13期

关键词：

SURFACE-PLASMON RESONANCE; LIVING CELLS; DEATH; SENSORS;

D O I：

10.1063/1.4822303

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Cell viability is a crucial issue in biological research. We present label-free monitoring of adhesion cells viability by gold nanoslits-based Fano resonance biosensors. Plastic multiple wells with gold nanoslits substrate were made using a thermal nanoimprint method. Adhesion cells in the wells were treated with doxorubicin for inducing cell death and compared with conventional colorimetric assay. The nanoslits method shows better respones of viability tests under low concentration and short interaction time due to its high surface sensitivies. The vinculin labelling indicates that the measured signals are in good agreement with the adhesion abilities of cells. (C) 2013 AIP Publishing LLC.

引用

页数：4

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