Efficient nucleophilic substitution reactions of quinolyl and isoquinolyl halides with nucleophiles under focused microwave irradiation

被引：32
|
作者：
Cherng, YJ [1 ]
机构：
[1] Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung 40605, Taiwan
来源：
TETRAHEDRON | 2002年 / 58卷 / 06期
关键词：
nucleophilic substitution reaction;
D O I：
10.1016/S0040-4020(01)01225-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nucleophilic substitution reactions of 2-chloroquinoline, 3-bromoquinoline and 4-bromoisoquinoline with thiolate, alkoxy ions and aniline were completed within several minutes under microwave irradiation. This method gives the desired products with yields up to 99% in a short reaction time, and is superior to the classical heating process. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1125 / 1129
页数：5
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