Efficient nucleophilic substitution reactions of quinolyl and isoquinolyl halides with nucleophiles under focused microwave irradiation

被引：32

作者：

Cherng, YJ ^{[1
]}

机构：

[1] Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung 40605, Taiwan

来源：

TETRAHEDRON | 2002年 / 58卷 / 06期

关键词：

nucleophilic substitution reaction;

D O I：

10.1016/S0040-4020(01)01225-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic substitution reactions of 2-chloroquinoline, 3-bromoquinoline and 4-bromoisoquinoline with thiolate, alkoxy ions and aniline were completed within several minutes under microwave irradiation. This method gives the desired products with yields up to 99% in a short reaction time, and is superior to the classical heating process. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1125 / 1129

页数：5

共 50 条

[1] Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles, under focused microwave irradiation
Cherng, YH
TETRAHEDRON, 2002, 58 (05) : 887 - 890
[2] Efficient nucleophilic substitution reaction of aryl halides with amino acids under focused microwave irradiation
Cherng, YJ
TETRAHEDRON, 2000, 56 (42) : 8287 - 8289
[3] Synthesis of substituted pyridines by the reactions of halopyridines with sulfur, oxygen and carbon nucleophiles under focused microwave irradiation
Cherng, YH
TETRAHEDRON, 2002, 58 (24) : 4931 - 4935
[4] Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation
Fang, WP
Cheng, YT
Cheng, YR
Cherng, YJ
TETRAHEDRON, 2005, 61 (12) : 3107 - 3113
[5] EFFECTS OF SUBSTITUENTS ON NUCLEOPHILES UNDER AROMATIC NUCLEOPHILIC SUBSTITUTION
BARTOLI, G
TODESCO, PE
CHIMICA & L INDUSTRIA, 1968, 50 (07): : 812 - &
[6] Efficient nucleophilic substitution reactions of highly functionalized allyl halides in ionic liquid media
Kotti, SRSS
Xu, X
Li, GG
Headley, AD
TETRAHEDRON LETTERS, 2004, 45 (07) : 1427 - 1431
[7] Nucleophilic substitution reaction in polyfluoroaromaticsⅠ.Reactions with secondary amine nucleophiles
GE Wen-Zheng WU Bao-Ming HUANG Wei-Yuan Shanghai Institute of Organic Chemistry
ActaChimicaSinica(EnglishEdition), 1985, (04) : 349 - 355
[8] Reactions of organomagnesates and aryl halides: Metalation and nucleophilic substitution
Farkas, J
Stoudt, SJ
Hanawalt, EM
Pajerski, AD
Richey, HG
ORGANOMETALLICS, 2004, 23 (03) : 423 - 427
[9] Substitution reaction of nitro group on α-nitrostyrene by organozinc halides under microwave irradiation
Hu, YL
Yu, JH
Yang, SY
Wang, JX
Yin, YQ
SYNTHETIC COMMUNICATIONS, 1999, 29 (07) : 1157 - 1164
[10] Substitution reaction of nitro group on α-nitrostyrene by organozinc halides under microwave irradiation
Stt. Key Lab. Oxo Synthesis S., Lanzhou Inst. of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
不详
Synth. Commun., 7 (1157-1164):

← 1 2 3 4 5 →