Outbreak of acute bovine viral diarrhea in Brazilian beef cattle: Clinicopathological findings and molecular characterization of a wild-type BVDV strain subtype 1b

被引：33

作者：

Lunardi, M. ^{[1
]}

Headley, S. A. ^{[2
]}

Lisboa, J. A. N. ^{[3
]}

Amude, A. M. ^{[1
]}

Alfieri, A. A. ^{[1
]}

机构：

[1] Univ Estadual Londrina, Dept Vet Prevent Med, Lab Anim Virol, BR-86051990 Londrina, Parana, Brazil

[2] Univ Helsinki, Fac Vet Med, Dept Vet Basic Sci, Helsinki, Finland

[3] Univ Estadual Londrina, Dept Vet Clin, BR-86051990 Londrina, Parana, Brazil

来源：

RESEARCH IN VETERINARY SCIENCE | 2008年 / 85卷 / 03期

关键词：

Cattle; Bovine viral diarrhea; Bovine viral diarrhea virus; 5 ' Untranslated region; Phylogenetic analysis;

D O I：

10.1016/j.rvsc.2008.01.002

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

When first described in 1946, bovine viral diarrhea (BVD) was characterized as an acute transmissible disease associated with severe leucopenia, high fever, depression, diarrhea, gastrointestinal erosions, and hemorrhages. Recently the severe acute form has been related only to some hypervirulent BVDV-2 strains. This article reports the detection of BVDV-1b associated with an acute and fatal outbreak of BVD in a Brazilian beef cattle herd. Depression, anorexia, watery diarrhea, sialorrhea, and weakness were observed in six steers. One of these animals was evaluated for laboratorial, clinical, and pathological alterations. Laboratory findings were non-specific; clinically, the animal was weak, with dehydration and erosive oral lesions. Pathological alterations were predominant at the tongue, esophagus, and rumen. A RT-PCR assay using primers to partially amplify the 5' untranslated region (5'UTR) of the BVDV genome was performed and identified BVDV in all clinical samples analyzed. Phylogenctic analysis of BVDV derived from lymph node revealed that this strain was clustered within the BVDV subtype 1b. This differentiating was only possible to be performed by molecular characterization since both clinical presentation and pathologic findings were similar to BVDV-2 infection. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：599 / 604

页数：6

共 12 条

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