This paper is concerned with the parabolic-elliptic Keller-Segel system with signal-dependent sensitivity chi(v), {u(t) = Delta u - del center dot (u del chi(v)) in Omega x (0,infinity), 0 = Delta v - v + u in Omega x (0, infinity), under homogeneous Neumann boundary condition in a smoothly bounded domain Omega subset of R-2 with nonnegative initial data u(0) is an element of C-0 ((Omega) over bar), not equivalent to 0. In the special case chi (v) = chi(0) log v (chi(0) > 0), global existence and boundedness of the solution to the system were proved under some smallness condition on chi(0) by Biler (1999) and Fujie, Winkler and Yokota (2015). In the present work, global existence and boundedness in the system will be established for general sensitivity chi satisfying chi' > 0 and chi'(s) -> 0 as s -> infinity. In particular, this establishes global existence and boundedness in the case chi(v) = chi(0) log v with large chi(0) > 0. Moreover, although the methods in the previous results are effective for only few specific cases, the present method can be applied to more general cases requiring only the essential conditions. Actually, our condition is necessary, since there are many radial blow-up solutions in the case inf s>0 chi'(s) > 0.