Inhibition of Mcl-1 Enhances the Efficacy of Tyrosine Kinase Inhibition in FLT3 Mutated AML and Synergizes with Venetoclax Targeting AML Stem Cells

被引:0
|
作者
Carter, Bing Z. [1 ]
Tao, Wenjing [1 ]
Mak, Po Yee [1 ]
Zhang, Qi [2 ]
Wang, Xiangmeng [1 ]
Kuruvilla, Vinitha Mary [3 ]
Stewart, Carli [2 ]
Ruvolo, Vivian [1 ]
Battula, Venkata Lokesh [1 ]
Konopleva, Marina Y. [1 ]
Caenepeel, Sean [4 ]
Canon, Jude [4 ]
Hughes, Paul [4 ]
Morrow, P. K. [4 ]
Andreeff, Michael [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Dept Leukemia, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[4] Amgen Inc, Thousand Oaks, CA 91320 USA
关键词
D O I
10.1182/blood-2019-125725
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1267
引用
收藏
页数:4
相关论文
共 50 条
  • [21] Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition
    Zhu, Ruiqi
    Shirley, Courtney M.
    Chu, S. Haihua
    Li, Li
    Nguyen, Bao H.
    Seo, Jaesung
    Wu, Min
    Seale, Tessa
    Duffield, Amy S.
    Staudt, Louis M.
    Levis, Mark
    Hu, Yu
    Small, Donald
    LEUKEMIA, 2024, 38 (07) : 1581 - 1591
  • [22] Inhibition of NOTCH4 Sensitizes FLT3/ITD Acute Myeloid Leukemia Cells to FLT3 Tyrosine Kinase Inhibition
    Zhu, Ruiqi
    Shirley, Courtney
    Chu, Haihua
    Li, Li
    Bao Nguyen
    Seo, Jaesung
    Seale, Tessa
    Duffield, Amy
    Staudt, Louis M.
    Levis, Mark J.
    Hu, Yu
    Small, Donald
    BLOOD, 2023, 142
  • [23] Menin Inhibition Decreases Bcl-2 and Bcl-xL and Enhances Venetoclax Activity in NPM1/FLT3-Mutated AML
    Carter, Bing
    Tao, Wenjing
    Mak, Po Yee
    Mak, Duncan
    Ostermann, Lauren
    Ordentlich, Peter
    McGeehan, Gerard
    Andreeff, Michael
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S277 - S278
  • [24] Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth
    Weir, Mark C.
    Hellwig, Sabine
    Tan, Li
    Liu, Yao
    Gray, Nathanael S.
    Smithgall, Thomas E.
    PLOS ONE, 2017, 12 (07):
  • [25] Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition
    Qiu, Shaowei
    Kumar, Harish
    Yan, Chengcheng
    Li, Hui
    Paterson, Andrew J.
    Anderson, Nicholas R.
    He, Jianbo
    Yang, Jing
    Xie, Min
    Crossman, David K.
    Lu, Rui
    Welner, Robert S.
    Bhatia, Ravi
    LEUKEMIA, 2022, 36 (11) : 2621 - 2633
  • [26] Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition
    Shaowei Qiu
    Harish Kumar
    Chengcheng Yan
    Hui Li
    Andrew J. Paterson
    Nicholas R. Anderson
    Jianbo He
    Jing Yang
    Min Xie
    David K. Crossman
    Rui Lu
    Robert S. Welner
    Ravi Bhatia
    Leukemia, 2022, 36 : 2621 - 2633
  • [27] FLT3 INHIBITION OVERCOMES RESISTANCE TO THE BCL-2 SELECTIVE ANTAGONIST, VENETOCLAX, IN FLT3-ITD MUTANT AML MODELS
    Sampath, D.
    Mali, R.
    Lasater, E.
    Doyle, K.
    Malla, R.
    Boghaert, E.
    Souers, A.
    Leverson, J.
    HAEMATOLOGICA, 2017, 102 : 42 - 42
  • [28] MEK inhibition to overcome venetoclax resistance in AML cell lines with activating FLT3 and PTPN11 mutations
    Fleischmann, M.
    Hansen, O.
    Schnetzke, U.
    Heidel, F. H.
    Mueller, J. P.
    Hochhaus, A.
    Scholl, S.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 93 - 93
  • [29] Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1
    Janssen, Maike
    Schmidt, Christina
    Bruch, Peter-Martin
    Blank, Maximilian F.
    Rohde, Christian
    Waclawiczek, Alexander
    Heid, Daniel
    Renders, Simon
    Goellner, Stefanie
    Vierbaum, Lisa
    Besenbeck, Birgit
    Herbst, Sophie A.
    Knoll, Mareike
    Kolb, Carolin
    Przybylla, Adriana
    Weidenauer, Katharina
    Ludwig, Anne Kathrin
    Fabre, Margarete
    Gu, Muxin
    Schlenk, Richard F.
    Stoelzel, Friedrich
    Bornhaeuser, Martin
    Roellig, Christoph
    Platzbecker, Uwe
    Baldus, Claudia
    Serve, Hubert
    Sauer, Tim
    Raffel, Simon
    Pabst, Caroline
    Vassiliou, George
    Vick, Binje
    Jeremias, Irmela
    Trumpp, Andreas
    Krijgsveld, Jeroen
    Mueller-Tidow, Carsten
    Dietrich, Sascha
    BLOOD, 2022, 140 (24) : 2594 - 2610
  • [30] Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation
    Kapoor, Shivani
    Natarajan, Karthika
    Baldwin, Patrick R.
    Doshi, Kshama A.
    Lapidus, Rena G.
    Mathias, Trevor J.
    Scarpa, Mario
    Trotta, Rossana
    Davila, Eduardo
    Kraus, Manfred
    Huszar, Dennis
    Tron, Adriana E.
    Perrotti, Danilo
    Baer, Maria R.
    CLINICAL CANCER RESEARCH, 2018, 24 (01) : 234 - 247