Synthesis of perylene bisimide-centered glycodendrimer and its interactions with concanavalin A

被引：17

作者：

Wang, Ke-Rang ^{[1
,2
]}

Wang, Yue-Qing ^{[1
,2
]}

Li, Jie ^{[3
]}

An, Hong-Wei ^{[1
,2
]}

Zhang, Li-Ping ^{[3
]}

Zhang, Jin-Chao ^{[1
,2
]}

Li, Xiao-Liu ^{[1
,2
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

[2] Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China

[3] Hebei Univ, Coll Life Sci, Baoding 071002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 02期

关键词：

Glycodendrimer; Concannavalin A; Perylene bisimide; Carbohydrate-lectin interactions; BINDING; GLYCOSYLATION; CANCER; DENDRIMERS; GLYCOMICS; SCAFFOLD; GLYCANS;

D O I：

10.1016/j.bmcl.2012.11.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel glycodendrimer based on 18 peripheral alpha-D-mannoses functionalized perylene bisimide derivative PBI-18-Man was synthesized and its selectively binding interactions for Con A were investigated by CD spectra and turbidity assay, which exhibited strong binding affinity for Con A with the binding constant of 1.3 x 10(8) M-1 (7.2 x 10(6) M-1 for monomeric mannose, valency corrected), 3 orders of magnitude higher affinity than the monovalent mannose ligand. Furthermore, the inhibitory activity for Con A was studied by ELLA experiment, showed 2 times inhibitor activity than the reference compound (alpha-MMP). Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：480 / 483

页数：4

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