A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells

被引：282
|
作者：
Liu, Tianyu [1 ,2 ]
Xu, Zhaochao [1 ,2 ]
Spring, David R. [3 ]
Cui, Jingnan [1 ]
机构：
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[3] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 09期
基金：
中国国家自然科学基金; 英国惠康基金; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
LARGE RED-SHIFT; RATIOMETRIC FLUORESCENT; NITRIC-OXIDE; CHEMOSENSOR; H2S; DEPROTONATION;
D O I：
10.1021/ol400973v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, a 1,8-naphthalimide-derived fluorescent probe for H2S based on the thiolysis of dinitrophenyl ether is reported. This probe exhibits turn-on fluorescence detection of H2S in bovine serum and lysosome-targetable fluorescent imaging of H2S with excellent selectivity.
引用
收藏
页码：2310 / 2313
页数：4
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