Polymer-bound auxiliaries for asymmetric synthesis no solid support:: New approaches to chiral, non-racemic drugs?

Polymer-bound chiral auxiliaries, which enable the asymmetric synthesis of non racemic compounds on solid support, have received increasing interest within the last few years. The chiral auxiliaries serve as anchoring groups, which allow diastereoselective transformations on the immobilized building blocks. This review presents the polymer-bound auxiliaries published so far and their application in asymmetric synthesis including acyl enolate chemistry, multi-component reactions, cycloadditions and nucleophilic additions to carbon-heteroatom double bonds.