Selective and potent benzoxazole inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase

被引:0
|
作者
Kavitha, Mandapati
Gorla, Suresh Kumar
Zhang, Minjia
Liu, Xiaoping
Sharling, Lisa
Gollapall, Deviprasad R.
Striepen, Boris
Cuny, Gregory D.
Hedstrom, Lizbeth
机构
[1] Brandeis Univ, Dept Biol, Waltham, MA 02254 USA
[2] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA
[3] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
[4] Harvard Univ, Sch Med, Lab Drug DiscoVery Neurodegenerat, Brigham & Womens Hosp, Cambridge, MA 02138 USA
[5] Brandeis Univ, Dept Chem, Waltham, MA 02254 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
373-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [41] The chemistry of nucleoside and dinucleotide inhibitors of inosine monophosphate dehydrogenase (IMPDH)
    Pankiewicz, KW
    Goldstein, BM
    RECENT ADVANCES IN NUCLEOSIDES: CHEMISTRY AND CHEMOTHERAPY, 2002, : 71 - 90
  • [42] Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase
    Iwanowicz, EJ
    Watterson, SH
    Liu, CJ
    Gu, HH
    Mitt, T
    Leftheris, K
    Barrish, JC
    Fleener, CA
    Rouleau, K
    Sherbina, NZ
    Hollenbaugh, DL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (20) : 2931 - 2934
  • [43] A novel series of non-nucleoside inhibitors of inosine 5′-monophosphate dehydrogenase with immunosuppressive activity
    Franklin, TJ
    Morris, WP
    Jacobs, VN
    Culbert, EJ
    Heys, CA
    Ward, WHJ
    Cook, PN
    Jung, F
    Plé, P
    BIOCHEMICAL PHARMACOLOGY, 1999, 58 (05) : 867 - 876
  • [44] Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors
    Sahu, Niteshkumar U.
    Purushothaman, Gayathri
    Thiruvenkatam, Vijay
    Kharkar, Prashant S.
    DRUG DEVELOPMENT RESEARCH, 2019, 80 (01) : 125 - 132
  • [45] Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors
    Sahu, Niteshkumar U.
    Singh, Vinayak
    Ferraris, Davide M.
    Rizzi, Menico
    Kharkar, Prashant S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (10) : 1714 - 1718
  • [46] In vitro and in vivo characterization of AS2643361, a novel and highly potent inosine 5′-monophosphate dehydrogenase inhibitor
    Nakanishi, Tomonori
    Kozuki, Yoshihiro
    Eikyu, Yoshiteru
    Kubo, Kaori
    Kawato, Yuka
    Marui, Takanori
    Seki, Nobuo
    Masunaga, Taro
    Tamura, Kouichi
    Morokata, Tatsuaki
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 674 (01) : 58 - 63
  • [47] Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum
    Nava, Maria G.
    Calderon, Felix
    Fernandez, Elena
    Ballell, Lluis
    Bamborough, Paul
    Vinayak, Sumiti
    MICROBIOLOGY SPECTRUM, 2023, 11 (01):
  • [48] Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum
    Li, Kun
    Nader, Sara M.
    Zhang, Xuejin
    Ray, Benjamin C.
    Kim, Chi Yong
    Das, Aditi
    Witola, William H.
    PLOS PATHOGENS, 2019, 15 (07)
  • [49] Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade
    Petrelli, Riccardo
    Vita, Patrizia
    Torquati, Ilaria
    Felczak, Krzysztof
    Wilson, Daniel J.
    Franchetti, Palmarisa
    Cappellacci, Loredana
    RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2013, 8 (02) : 103 - 125
  • [50] STIMULATION OF PARTHENOGENESIS IN MOUSE OVARIAN FOLLICLES BY INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE
    DOWNS, SM
    BIOLOGY OF REPRODUCTION, 1990, 43 (03) : 427 - 436