Synthesis of Dehydroabietane-derived Sulfonamides with a Lysine Fragment

被引：3

作者：

Pestova, S. V. ^{[1
]}

Petukhov, D. V. ^{[2
]}

Izmest'ev, E. S. ^{[1
]}

Rubtsova, S. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem, Fed Res Ctr, Komi Sci Ctr,Ural Branch, Syktyvkar 167000, Russia

[2] Vyatka State Univ, Kirov 6170000, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 08期

关键词：

diterpenoids; lysine; hydrazides; sulfonamides; sulfonic acids; sulfochlorides; BETULINIC ACID; DERIVATIVES; ESTERS;

D O I：

10.1134/S1070428022080139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mono- and bis-sulfonamide derivatives of l-lysine were obtained for the first time by the reaction of methyl lysinate with ethyl 12-sulfodehydroabietate. Sulfonamides containing an additional sulfonamide or amide group in the alpha-position of lysine were synthesized by involving camphor-10-sulfonyl chloride, as well as isonicotinoyl, benzoyl, and alpha-naphthoyl chlorides in the reaction. The corresponding hydrazide and acid were also prepared by the modification of the ester group of N-dehydroabietane-derived methyl lysinate.

引用

页码：1170 / 1177

页数：8

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