Antitumor activity of transition metal(II) complexes with all-trans retinoic acid

被引：8
|
作者：
Liu, YM
Wang, LF [1 ]
Wang, ZP
Zhang, ZH
Chen, YR
Xu, JW
机构：
[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Med Coll, Lanzhou 730000, Peoples R China
[3] Anal & Testing Ctr Gansu Prov, Lanzhou 730000, Peoples R China
来源：
TRANSITION METAL CHEMISTRY | 1999年 / 24卷 / 01期
关键词：
D O I：
10.1023/A:1006937915080
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Five complexes of transition metals with all-trans retinoic acid (HRA) have been prepared and characterized by elemental analysis, molar conductance, t.g. -d.t.a, i.r., and u.v.-vis. spectroscopy, and H-1-n.m.r. spectrometry. The general formula of these complexes is ML2. nH(2)O where L = RA, M = Mn-II, Co, Ni-II, Cu-II, Zn-II, and n = 3 or 4. They have been studied for their antitumour activity against human bladder cancer line EJ (EJ cells) with respect to proliferation, induce differentiation, P-21 and mutation P-53 expressions in vitro.
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页码：1 / 4
页数：4
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