Antitumor activity of transition metal(II) complexes with all-trans retinoic acid

被引：8

作者：

Liu, YM

Wang, LF ^{[1
]}

Wang, ZP

Zhang, ZH

Chen, YR

Xu, JW

机构：

[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Med Coll, Lanzhou 730000, Peoples R China

[3] Anal & Testing Ctr Gansu Prov, Lanzhou 730000, Peoples R China

来源：

TRANSITION METAL CHEMISTRY | 1999年 / 24卷 / 01期

关键词：

D O I：

10.1023/A:1006937915080

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Five complexes of transition metals with all-trans retinoic acid (HRA) have been prepared and characterized by elemental analysis, molar conductance, t.g. -d.t.a, i.r., and u.v.-vis. spectroscopy, and H-1-n.m.r. spectrometry. The general formula of these complexes is ML2. nH(2)O where L = RA, M = Mn-II, Co, Ni-II, Cu-II, Zn-II, and n = 3 or 4. They have been studied for their antitumour activity against human bladder cancer line EJ (EJ cells) with respect to proliferation, induce differentiation, P-21 and mutation P-53 expressions in vitro.

引用

页码：1 / 4

页数：4

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