Simultaneous Integrated Boost-Intensity-Modulated Radiotherapy in Head and Neck Cancer

被引：13

作者：

Franceschini, Davide ^{[1
]}

Paiar, Fabiola ^{[1
]}

Meattini, Icro ^{[1
]}

Agresti, Benedetta ^{[1
]}

Pasquetti, Eleonora Monteleone ^{[1
]}

Greto, Daniela ^{[1
]}

Bonomo, Pierluigi ^{[3
]}

Marrazzo, Livia ^{[2
]}

Casati, Marta ^{[2
]}

Livi, Lorenzo ^{[3
]}

Biti, Giampaolo ^{[1
]}

机构：

[1] Univ Florence, Dept Radiat Oncol, IFCA, I-50134 Florence, Italy

[2] Univ Florence, Dept Med Phys, IFCA, I-50134 Florence, Italy

[3] Univ Florence, Radiotherapy Unit, IFCA, I-50134 Florence, Italy

来源：

LARYNGOSCOPE | 2013年 / 123卷 / 12期

关键词：

Radiotherapy; head and neck; chemotherapy; QUALITY-OF-LIFE; LOCALLY ADVANCED HEAD; RADIATION-THERAPY; OROPHARYNGEAL CARCINOMA; TARGET COVERAGE; IMRT; UPDATE; FRACTIONATION; IRRADIATION; AMIFOSTINE;

D O I：

10.1002/lary.24257

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives/HypothesisTo review toxicity and outcomes in patients with head and neck cancer treated with simultaneous integrated boost-intensity-modulated radiotherapy (SIB-IMRT). Study DesignReview of experience with the SIB-IMRT technique. MethodsFifty patients were treated with the SIB-IMRT technique. Two possible schedules of radiation therapy (RT) were used: SIB 70 (70/60/54 in 33 fractions) and SIB 66 (66/60/54 in 33 fractions). Forty-one patients also received chemotherapy. ResultsAll but two patients completed treatment as prescribed. No G4 acute toxicity has been reported in our series. We did not observe any G3 to G4 chronic toxicity, apart from one case of cutaneous necrosis. After a median follow-up of 23.3 months (range, 1-60 months), 41 patients (82%) were alive and negative for disease, and one patient (2%) was alive with distant metastases. Eight patients (16%) died, seven because of progressive disease and one for other causes. ConclusionsSIB-IMRT is a highly effective and safe technique of RT in the treatment of head and neck cancer. Level of Evidence4 Laryngoscope, 123:E97-E103, 2013

引用

页码：E97 / E103

页数：7

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