Pediatric kidney transplantation

被引:3
|
作者
Badet, L. [1 ]
Matillon, X. [1 ]
Codas, R. [1 ]
Timsit, M. -O. [2 ]
Thuret, R. [3 ]
Kleinclauss, F. [4 ]
Demede, D. [5 ]
机构
[1] Univ Claude Bernard Lyon 1, Hop Edouard Herriot, Serv Urol & Chirurg Transplantat, HCL, 5 Pl Arsonval, F-69437 Lyon 03, France
[2] Univ Paris 05, Hop Europeen Georges Pompidou, Serv Urol & Transplantat Renale, F-75015 Paris, France
[3] Univ Montpellier, CHU Montpellier, Serv Urol & Transplantat Renale, F-34000 Montpellier, France
[4] Univ Franche Comte, CHRU Besancon, Serv Urol & Transplantat Renale, Inserm UMR 1098, F-25000 Besancon, France
[5] Univ Claude Bernard Lyon 1, Hop Mere Enfant, HCL, Serv Chirurg Pediat, F-69437 Lyon, France
来源
PROGRES EN UROLOGIE | 2016年 / 26卷 / 15期
关键词
Kidney transplantation; Pediatric; Children; Outcomes; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; RENAL-TRANSPLANTATION; UNITED-STATES; SINGLE-CENTER; CHILDREN; RECIPIENTS; GRAFT; SURVIVAL; GROWTH;
D O I
10.1016/j.purol.2016.08.011
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Aims. - To describe indications, surgical aspects, results and outcomes of kidney transplantation in children. Material and methods. An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http: //www.embase.com) using different associations of the following keywords (MESH): "kidney transplantation", "pediatric", "children", "outcomes". Publications obtained were selected based on methodology, language, date of publication (last 10 years) and relevance. Prospective and retrospective studies, in English or French, review articles; meta-analysis and guidelines were selected and analyzed. This search found 2608 articles. After reading titles and abstracts, 18 were included in the text based on their relevance. Results. - Kidney transplantation is the gold-standard treatment for end stage renal kidney disease in children. The surgical procedure is well standardized with a retroperitoneal approach when child and kidney size allow it or a transperitoneal approach in child less than 15 kg and big size kidney graft. Anastomosis sites include iliac vessels in the retroperitoneal approach, and inferior vena cava and aorta in case of transperitoneal procedure. Ureteral reimplantation used most of the time a Campos Freire technique. Sometimes, particular conditions in the recipient (such as vena cava thrombosis) required procedure adaptation. Conclusion. - Graft survival dramatically increased over the past few years and is now superior to those observed in adult kidney transplantation, particularly in experienced team with microsurgery skills. Immunosuppressive treatments are similar to adults. Viral infections and post-transplant lymphoproliferative disorder are the main complications of renal transplantation in children and may lead to lethal outcomes. An increase graft toss is observed during boyhood due to immunosuppressive drugs uncompliance. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:1045 / 1052
页数:8
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