Understanding the effects of RAF inhibitors on RAF signaling in B-RAF V600E mutant versus wild type tumors

被引：0
|
作者：
Yen, Ivana
Song, Kyung
Stokoe, David
Brandhuber, Barbara
Gloor, Susan
Aliagas, Ignacio
Anderson, Daniel
Morales, Tony
Vigers, Guy
Ludlam, Mary
Alvarado, Ryan
Liu, Bonnie
Sideris, Steve
Ramaswamy, Sreema
Heise, Christopher
Belvin, Marcia
Friedman, Lou
Hatzivassiliou, Georgia
Malek, Shiva
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2009年 / 8卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-09-B90
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B90
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
    Roering, Michael
    Herr, Ricarda
    Fiala, Gina J.
    Heilmann, Katharina
    Braun, Sandra
    Eisenhardt, Anja E.
    Halbach, Sebastian
    Capper, David
    von Deimling, Andreas
    Schamel, Wolfgang W.
    Saunders, Darren N.
    Brummer, Tilman
    EMBO JOURNAL, 2012, 31 (11): : 2629 - 2647
  • [22] The mechanism of activation of monomeric B-Raf V600E.
    Maloney, Ryan C.
    Zhang, Mingzhen
    Jang, Hyunbum
    Nussinov, Ruth
    CANCER RESEARCH, 2021, 81 (13)
  • [23] Discovery of potent, selective inhibitors of mutant B-Raf
    Palmer, Cynthia L.
    Cui, Jingrong
    Deal, Judith
    Gu, Danlin
    Guo, Chuangxing
    Kephart, Susan
    Linton, Maria A.
    McAlpine, Indrawan
    Pairish, Mason
    Bagrodia, Shubha
    Cao, Yixue
    Yamazaki, Shinji
    DeLisle, Dorothy
    John-Baptiste, Annette
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [24] Phenol-pyrazole inhibitors of mutant B-raf
    McAlpine, Indrawan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [25] Mutant B-Raf Kinase Inhibitors as Anticancer Agents
    Asati, Vivek
    Bharti, Sanjay K.
    Mahapatra, Debarshi K.
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016, 16 (12) : 1558 - 1575
  • [26] Allosteric communication within the B-Raf dimer: The effect of the V600E mutation and inhibitor binding
    Marino, Kristen A.
    Gervasio, Francesco L.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [27] Noninvasive Drug Delivery Using Ultrasound: Targeting Melanoma Using siRNA Against Mutant (V600E) B-Raf
    Tran, Melissa A.
    Gowda, Raghavendra
    Park, Eun-Joo
    Adair, James
    Smith, Nadine
    Kester, Mark
    Robertson, Gavin P.
    8TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, 2009, 1113 : 423 - +
  • [28] Absence of V600E B-RAF Mutation in MLH1-Negative Endometrial Carcinoma
    Musulen, E.
    Munoz-Marmol, A. M.
    Sanz, C.
    Carrato, C.
    Mate, J. L.
    Ariza, A.
    MODERN PATHOLOGY, 2011, 24 : 261A - 261A
  • [29] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
    Garnett, MJ
    Rana, S
    Paterson, H
    Barford, D
    Marais, R
    MOLECULAR CELL, 2005, 20 (06) : 963 - 969
  • [30] Small molecule modulators of B-Raf conformational switching pockets for treatment of human cancers. Inhibitors of wt and V600E, T5291/V600E mutant forms
    Flynn, Daniel
    Kaufman, Mike
    Lu, Wei Ping
    Petillo, Peter A.
    Wise, Scott C.
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3596S - 3596S
12345