Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

被引：8

作者：

Meng, Ying ^{[1
]}

Wang, Guan ^{[2
]}

Li, Yue ^{[1
]}

Hou, Kuan ^{[1
]}

Yuan, Yue ^{[1
]}

Zhang, Li-Juan ^{[1
]}

Song, Hong-Rui ^{[1
]}

Shi, Wei ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130012, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2013年 / 24卷 / 07期

关键词：

Pyrrolopyrazinone; Antitumor; Synthesis;

D O I：

10.1016/j.cclet.2013.04.020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of pyrrolo[1,2-a]pyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MU method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. (C) 2013 Hong-Rui Song and Wei Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：619 / 621

页数：3

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