The filarial and the antibiotics: Single or combination therapy using antibiotics for filariasis

被引：4
|
作者：
Fordjour, Fatima Amponsah [1 ,2 ]
Kwarteng, Alexander [2 ,3 ]
机构：
[1] Univ Dev Studies UDS, Dept Microbiol, Tamale, Ghana
[2] Kwame Nkrumah Univ Sci & Technol KNUST, Dept Biochem & Biotechnol, Kumasi, Ghana
[3] Kwame Nkrumah Univ Sci & Technol KNUST, Kumasi Ctr Collaborat Res Trop Med, Kumasi, Ghana
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷
关键词：
filariasis; antibiotics; mass drug administration; neglected tropical diseases; Wolbachia; GROWTH FACTOR-A; BRUGIA-MALAYI; WUCHERERIA-BANCROFTI; LITOMOSOIDES-SIGMODONTIS; WOLBACHIA ENDOBACTERIA; ANTIFILARIAL ACTIVITY; DRUG-RESISTANCE; IVERMECTIN; DOXYCYCLINE; ONCHOCERCIASIS;
D O I：
10.3389/fcimb.2022.1044412
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Filarial infections caused by nematodes are one of the major neglected tropical diseases with public health concern. Although there is significant decrease in microfilariae (mf) prevalence following mass drug administration (IVM/DEC/ALB administration), this is transient, in that there is reported microfilaria repopulation 6-12 months after treatment. Wolbachia bacteria have been recommended as a novel target presenting antibiotic-based treatment for filarial disease. Potency of antibiotics against filarial diseases is undoubtful, however, the duration for treatment remains a hurdle yet to be overcome in filarial disease treatment.
引用
收藏
页数：10
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